The Drive with Peter Attia — Lp(a)

On: Deep Dive Lp(a).

Episode: 7

Date: July 2018

Key Subjects:

  • See Cholesterol write-up.
  • Lp(a) is an LDL particle with an extra apo(a) protein added on, hence the “little a.”
  • Lp(a) molecules differs in size based on length of the tail (Kringle domain).
  • Evolutionary function:
    • Blood clotting, scavenger of inflammatory molecules (oxidized phospholipids).
  • In chronic inflammation environment, high Lp(a) increases the risk of CVD.
  • Treatment: Niacin (not widely used), Statins (no), PCSK9 (yes).

Key Takeaways:

  • May help to know Lp(a) isoform (Kringle domain type).

Worth Listening:

  • 7/10

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