On: Deep Dive Lp(a).
Date: July 2018
- See Cholesterol write-up.
- Lp(a) is an LDL particle with an extra apo(a) protein added on, hence the “little a.”
- Lp(a) molecules differs in size based on length of the tail (Kringle domain).
- Evolutionary function:
- Blood clotting, scavenger of inflammatory molecules (oxidized phospholipids).
- In chronic inflammation environment, high Lp(a) increases the risk of CVD.
- Treatment: Niacin (not widely used), Statins (no), PCSK9 (yes).
- May help to know Lp(a) isoform (Kringle domain type).