Fructose and Glucose (and a Bit of Salt)

Key Takeaways: Fructose and glucose are very similar simple carbohydrates. Fructose is found in fruits and vegetables. Glucose is made by plants, mostly consumed in bonded form (lactose, starch, etc.). Fructose and glucose play a role in the storage and

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Ageing

Summary Introduction. Ageing and disease. Nine Hallmarks of Ageing. Genomic Instability. Telomere Attrition. Epigenetic Alterations. Cellular Senescence. Deregulated Nutrient Sensing Mitochondrial Dysfunction. Stem Cell Exhaustion. Loss of Proteostasis. Altered Intercellular Communication. Ageing and Cognitive Diseases. Ageing and Dietary Restriction (DR).

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Fatty Acids

Summary Introduction. Saturated Fatty Acids. Unsaturated Fatty Acids. MUFA — Omega-9. PUFA — Omega-3. PUFA — Omega-6. Omega-6 to Omega-3 Ratio. Lower Omega-6. Moderately Increase Omega-3. Supplement GLA. Role in Early Life. Introduction Fats. One of the five macro-nutrients. Made

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Sirtuins

Summary Introduction. Sirtuins and Gene Silencing. Sirtuins Activity. Sirtuins and Senescence. Introduction Silent information regulator (SIR). Crossroads of nutrient sensing and stress regulation. Responds to energy and nutrients. Controls cellular health. Regulates adaptive response to energy availability. Silences genes. Repairs

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Methylation

This summary was put together based on a wide variety of public information, much of it from Wikipedia. Certain sections of the summary below borrow heavily from the podcast “The Drive with Peter Attia — Chris Masterjohn“ where methylation is

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Type 1 Diabetes

This summary relies heavily on the podcast “The Drive with Peter Attia — Jake Kushner“. The show-notes of this excellent episode contain more relevant details, charts, book recommendations and resource links. Any mistakes in the summary below are mine. Summary

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mTOR

Summary Introduction. mTOR Activation and Inhibition. Rapamycin. Sources. Introduction Mammalian target of rapamycin (mTOR). Involved in cell metabolism, survival, and growth Central regulator of metabolism and physiology. Regulates many cellular processes. Ccell growth, proliferation, protein synthesis, autophagy. Within the cell,

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