Why does COVID-19 disproportionately affect the elderly?

By: Amber L. Mueller, Maeve S. McNamara, David A. Sinclair Glenn Center for Biology of Aging Research, Blavatnik Institute, Harvard Medical School Preprint, 30 April 2020 – not peer reviewed. Summary Severity and outcome of COVID-19 largely depends on a

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Interventions for Human Frailty: Physical Activity as a Model

By: Linda P. Fried In: Cold Spring Harbor Perspectives in Medicine, 2016 Jun 1. Date: 2016 Summary Life span has expanded. Added about 30 years in life span over the last 100 years. Mostly due to: Public health interventions targeting infectious

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Life’s Information Hierarchy

The explanation for the complex, multi-scale structure of biological and social systems lies in their manipulation of space and time to reduce uncertainty about the future. By: Jessica C. Flack Date: April 2014 In: Santa Fe Institute Bulletin and From

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Circuit Breakers

By: Luca Dellanna Date: April 21, 2020 In: Personal Blog Key Subjects Regulations tend to be optimized for everyday life. Not for emergency situations (such as the current pandemic). Need for circuit breakers. Alternative regulations that kick-in fast during an

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How does coronavirus kill?

Clinicians trace a ferocious rampage through the body, from brain to toes. By: Meredith Wadman, Jennifer Couzin-Frankel, Jocelyn Kaiser, Catherine Matacic In: Science. Apr. 17, 2020 How does the virus attack cells around the body? A clear picture is elusive.

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Sleeping with the Baby

By: John Seabrook In: New Yorker, October 2015 Babies and sleep. Polyphasic sleep. Babies tend to sleep in bouts, not distinguishing between night and day. Opposite of monophasic sleep: one seven- or eight-hour chunk at night. REM sleep (dream stage).

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The Fragile Generation

Bad policy and paranoid parenting are making kids too safe to succeed. By: Lenore Skenazy and Jonathan Haidt In: Reason, December 2017 Summary Key claim: kids are over-protected and under-prepared. We raise kids unaccustomed to facing anything on their own,

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The information theory of individuality

By: David Krakauer, Nils Bertschinger, Eckehard Olbrich, Jessica C. Flack, Nihat Ay In: Theory in Biosciences Date: 24 March, 2020 Introduction There is little agreement (in biology) about what individuals are. Few rigorous quantitative methods for their identification. Information theory

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Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections

By: Alex Zhavoronkov In: Aging Date: 31 March, 2020 Summary COVID-19 disproportionately harms the elderly. Infection rates, severity, and lethality all increase with age. Mostly because of higher levels of comorbidity among elderly. May also be due to decreased immune

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Estimating the number of infections and the impact of nonpharmaceutical interventions on COVID-19 in 11 European countries

By: Seth Flaxman, Swapnil Mishra, Axel Gandy, H Juliette T Unwin, Helen Coupland, Thomas A Mellan, Harrison Zhu, Tresnia Berah, Jeffrey W Eaton, Pablo N P Guzman, Nora Schmit, Lucia Callizo, Kylie E C Ainslie, Marc Baguelin, Isobel Blake, Adhiratha

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