On: performance and longevity paradox of IGF-1, ketogenic diets and genetics, health benefits of sauna, NAD+

Episode: 2

Date: July 2018

Key Subjects:

• Importance of concept of cycling:
  • For instance,growth factor (IGF-1) has benefits when it high and when it is low:
    • When high, good against heart disease and neurodegenerative disease; when low, lower risk of cancer.
    • Also good and bad at different times; for instance, having higher levels of IGF-1 may be more important at a higher age bracket (DNA repair).
  • In the fasting cycle, both the body’s response to fasting, as well as the body’s response to re-feeding is important in terms of potential benefits.
    • While fasting, organs shrink (and remove damaged cells); while re-feeding, cell growth is re-activated (with new healthy cells).
    • Pursuing caloric restriction only provides you the benefits of fasting only (half the cycle).
    • Better to pursue periodic fasting and/or ketogenic diets.
• Fasting as a beneficial complementary treatment for cancer (see Fasting write-up).
• Exercise provides an IGF-1 boost where it is needed (muscle and brain tissue).
• Sauna has multiple benefits (mood, immune system, etc.) (see Sauna write-up).
• Decline of NAD+ in aging.

Key Takeaways:

• Get biomarker report (https://www.foundmyfitness.com/genetics).
• Get newsletter (https://www.foundmyfitness.com).
• Ketogenic diet may not be for everyone (the higher fat content, especially saturated fat may result in higher LDL cholesterol)
• Use sauna.

Worth Listening:

Perhaps covers too much ground and therefore (uncharacteristically for this podcast) doesn’t go too deep into interesting parts.

6/10