The Drive with Peter Attia — Rhonda Patrick

On: performance and longevity paradox of IGF-1, ketogenic diets and genetics, health benefits of sauna, NAD+

Episode: 2

Date: July 2018

Key Subjects:

  • Importance of concept of cycling:
    • For instance,growth factor (IGF-1) has benefits when it high and when it is low:
      • When high, good against heart disease and neurodegenerative disease; when low, lower risk of cancer.
      • Also good and bad at different times; for instance, having higher levels of IGF-1 may be more important at a higher age bracket (DNA repair).
    • In the fasting cycle, both the body’s response to fasting, as well as the body’s response to re-feeding is important in terms of potential benefits.
      • While fasting, organs shrink (and remove damaged cells); while re-feeding, cell growth is re-activated (with new healthy cells).
      • Pursuing caloric restriction only provides you the benefits of fasting only (half the cycle).
      • Better to pursue periodic fasting and/or ketogenic diets.
  • Fasting as a beneficial complementary treatment for cancer (see Fasting write-up).
  • Exercise provides an IGF-1 boost where it is needed (muscle and brain tissue).
  • Sauna has multiple benefits (mood, immune system, etc.) (see Sauna write-up).
  • Decline of NAD+ in aging.

Key Takeaways:

Worth Listening:

Perhaps covers too much ground and therefore (uncharacteristically for this podcast) doesn’t go too deep into interesting parts.


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