FoundMyFitness — Roland Griffiths

On: Psilocybin, Psychedelic Therapies & Mystical Experiences

Episode: N/A

Date: January 2017

Key Subjects:

  • Common experiences in usage of psilocybin:
    • Beneficial impact lasts for reasonably long period after usage.
    • During usage: sense of interconnectedness, authenticity / truth value.
  • Psilocybin can act as anti-depressant by binding with serotonin re-uptake receptors.
    • Similar to how SSRI drugs work.
    • Potentially also drives growth of new neurons (breaking old connections, forming new).
  • Can also help alleviate depression by deactivating the default mode network.
    • DMN: self-referential processing, sense of self.
    • Similar effects as meditation.
  • Broadly reorganizes neuronal connections in the brain.
    • Capable of changing fixed set points.
    • Helpful in dealing with addictions.
  • Dosage dependent.
    • Low threshold of 5 mg; 20-30 mg (per 70 kg) may be sweet spot.

Key Takeaways:

  • Broad impact of psychedelics on brain activity.

Worth Listening:


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