FoundMyFitness — Guido Kroemer

On: Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation

Episode: N/A

Date: July 2017

Key Subjects:

  • See Autophagy write-up.
  • Autophagy is an evolutionary tool to remove damaged cell parts in response to environmental stress in a targeted manner allowing for regeneration.
  • Fasting may be one of the mechanisms to bring about autophagy.
    • May help in allowing the body to recover from stress, inflammation.
    • Discussion provides a helpful reminder of difficulty in comparing mice trials to human experience in fasting:
      • When mice fast for 2 days, they lose about 20% of their body weight…
  • Spermidine seems to induce autophagy (as does caffeine…):
    • Alternative for fasting.

Key Takeaways:

Worth Listening:

Dry and technical, but helpful primer on autophagy.


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