On: Part V of V: Lp(a), inflammation, oxLDL, remnants, and more.
Date: October 2018
- Lp(a) is a particularly high risk lipoprotein.
- Important to know your Lp(a) mass or particle count.
- Three factors contributing to increased risk of CVD.
- Cholesterol, chronic inflammation, endothelial function.
- Chronic inflammation:
- Important to measure your inflammation levels.
- Measure levels of oxidative stress (oxLDL or F2-isoprostanes).
- Endothelial function:
- Measure SDMA and ADMA as biomarkers for endothelial function.
- Both inhibit production of nitric oxide, which regulates endothelial function.
- High homocysteine as well as oxidative stress prevent the breakdown of SDMA/ADMA and thereby contribute to lower nitric oxide and decreased endothelial functioning.
- So if homocysteine is high, need to lower it…
- Lipoproteins of any type that fail to get cleared.
- Dangerous because they become more cholesterol rich the longer they circulate.
- apoC-III plays an important role in retarding the clearance of lipoproteins.
- Important to measure apoC-III biomarker.
- Statins may not work well on LDL particles with apoC-III.
- Drug being developed to stop apoC-III synthesis in the liver (antisense drugs).
- Measure oxidative stress (preferred: F2-isoprostanes; if high Lp(a): Lp-PLA2).
- Measure endothelial function: ADMA and SDMA.
- Measure apoC-III (to understand importance of remnants, potential resistance to statins).