On: Part II of V: Lipid metrics, lipid measurements, and cholesterol regulation.
Date: July 2018
- Lipid basics.
- Lipoproteins are needed to carry lipids around the bloodstream.
- The lipids carried primarily include triglycerides, cholesterol, phospholipids.
- Various types of lipoproteins.
- Based on density (protein to lipid ratio).
- Types of protein attached to the lipoprotein molecule (apoB, apoA, apoC – subsets of those, etc.).
- apoB lipoproteins (= LDL)
- The ones that get trapped in artery walls.
- 95% of apoB is attached to LDL lipoproteins (one-to-one).
- The higher the LDL particle count, the higher the risk of particles getting trapped.
- Knowing LDL particle count is #1 risk indicator to check.
- Would also be good to have an insight into cholesterol flow mechanics: the synthesis, influx and efflux of cholesterol.
- But there are no good markers for flux.
- Absorption: test for plant sterol absorption (weak marker).
- Synthesis: test for cholesterol precursors such as desmasterol (decent marker).
Test for apoB or LDL particle number.
Test for cholesterol absorption and synthesis markers (if needed).