Avoid or do less.
- Reduce harm by removing things, rather than adding to it.
- May not make sense to add supplements:
Figure out.
- Measure, test to identify specific (genetic) requirements (see “Tests“).
- Determine proper brand of supplement (reputation, ingredients, etc.).
- Same for drugs, especially generic drugs (“The Drive with Peter Attia — Katherine Eban“)
- Add supplement selectively, re-test after period of usage.
Selected supplements to consider
- Reputable brands:
- Jarrow. (“The Drive with Peter Attia — Ron Kraus“)
- Thorne.
- Nordic Naturals.
- Sulforaphane: (“FoundMyFitness — Jed Fahey“) (“Sulforaphane“)
- To lower inflammation and oxidative stress
- Brand: Thorne (GRN only) or Avmacol (GRN + MYR).
- Creatine: (“The Drive with Peter Attia — Chris Masterjohn“)
- To reduce methylation demands.
- Brand: Thorne.
- B-Complex: (“Methylation“)
- To promote more efficient methylation.
- Understand if you have methylation pathway issues.
- Do you need to lower homocysteine (better conversion and/or breakdown).
- Depending on genetic profile, pick appropriate B vitamin or complex.
- Brand: Thorne.
- Glycine: (“The Drive with Peter Attia — Chris Masterjohn“)
- May be low due if overly methylated and peed out (in homocysteine breakdown).
- Helps with sleep.
- Brand: [No need for supplementing].
- Omega-3: (“Fatty Acids“)
- EPA and DHA, improve Omega-6 to Omega-3 ratio.
- Brand: Nordic Naturals
- GLA / Borage oil: (“Fatty Acids“)
- Preferred form of Omega-6 (anti-inflammatory).
- In combination with Omega-3 (to avoid pro inflammatory impact).
- Brand: Jarrow.
- NAD+: (“The Drive with Peter Attia — Chris Masterjohn“)
- Promote DNA repair (activate sirtuins).
- In combination with a methyl donor (choline, betaine, TMG).
- Impact, side and signaling effects unclear.
- NR supplement
- Brand: Tru Niagen discussed.
- Curcumin: (“Nutrition — Cholesterol“)
- Boosts DHA, digestive health.
- Berberine: (“Nutrition — Cholesterol“)
- Commonly taken for diabetes, high cholesterol, and high blood pressure.
- Helps to lower both cholesterol and triglycerides.
- Brand: Thorne.