On: Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis
Date: October 2016
- See Fasting write-up
- A shielding and repair mode that we lost over time.
- Two modes: fasting and (re-)feeding.
- Both modes have provide different sets of stressors to the body.
- Fasting is likely the more common mode of the body than eating.
- Fasting = shielding and repair (slow down growth and re-productivity).
- Refeeding = grow and reproduce.
- Importance of cycles of fasting and feeding:
- During fast: clear out the damaged cells, trigger stem cells.
- During feeding: regrowth from stem cells.
- Protein intake during refeeding important to help increase IGF-1.
- Prolonged fasting or fasting mimicking diet are the only versions that trigger the benefits of IGF-1 cycling.
- Potential to use fasting protocol as complementary therapy in cancer and other diseases:
- General concept of differential stress resistance: strengthen normal cells, weaken damaged cells.
- Use metabolic pathways to increase the stress on cancer cells and slow their growth, while strengthening normal cells.
The approach is to activate these metabolic pathways essentially through dietary means (in combination with pursuing the standard of care).
One of the pillars of the approach is to reduce carbs (and proteins) and increase intake of (healthy) fats and ketones, basically to follow a ketogenic diet.
There seems to be a fairly broad body of science showing that reducing glucose and increasing ketones can have a wide array of potentially positive effects.
Intermittent fasting may have a similar effect (as it also brings about ketosis).
There are some other components to the approach that are non-dietary.
- Together, they are sometimes referred to as the “Press Pulse” protocol.
- Risk of using metformin:
- Not knowing long term impact of blocking key pathways in cells.
- Exercise has similar cyclical impact as fasting:
- Damage tissue, repair tissue; also triggers IGF-1 usage.
- Fasting is not a stress on the body, but a shielding and repair mode that we lost over time.
- Prolonged fasting or fasting mimicking diet are the only versions of fasting that trigger the benefits of (IGF-1) cycling.
- Exercise has similar cyclical impact as fasting: damage tissue, repair tissue, trigger IGF-1 for re-growth.
- Prolon FMD: fasting mimicking diet product (https://prolonfmd.com/).
“Press Pulse” cancer-related fasting protocol:
Thomas SEYFRIED Rethinking Cancer Paris 2017 — (https://www.youtube.com/watch?v=3TZnjC7SR_w&t=309s)
Valter LONGO Rethinking Cancer Paris 2017 — (https://www.youtube.com/watch?v=v4ame4E1rtE&t=12s)
Adrienne C. Scheck, PhD — The Ketogenic Diet as an Adjuvant to Standard of Care — (https://www.youtube.com/watch?v=vMOhFmY8S-Q)