On: Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis

Episode: N/A

Date: October 2016

Key Subjects:

• See Fasting write-up
• A shielding and repair mode that we lost over time.
  • Two modes: fasting and (re-)feeding.
  • Both modes have provide different sets of stressors to the body.
  • Fasting is likely the more common mode of the body than eating.
  • Fasting = shielding and repair (slow down growth and re-productivity).
  • Refeeding = grow and reproduce.
• Importance of cycles of fasting and feeding:
  • During fast: clear out the damaged cells, trigger stem cells.
  • During feeding: regrowth from stem cells.
  • Protein intake during refeeding important to help increase IGF-1.
  • Prolonged fasting or fasting mimicking diet are the only versions that trigger the benefits of IGF-1 cycling.
• Potential to use fasting protocol as complementary therapy in cancer and other diseases:
  • General concept of differential stress resistance: strengthen normal cells, weaken damaged cells.
  • Use metabolic pathways to increase the stress on cancer cells and slow their growth, while strengthening normal cells.

  • The approach is to activate these metabolic pathways essentially through dietary means (in combination with pursuing the standard of care).

  • One of the pillars of the approach is to reduce carbs (and proteins) and increase intake of (healthy) fats and ketones, basically to follow a ketogenic diet.

  • There seems to be a fairly broad body of science showing that reducing glucose and increasing ketones can have a wide array of potentially positive effects.

  • Intermittent fasting may have a similar effect (as it also brings about ketosis).

  • There are some other components to the approach that are non-dietary.

  • Together, they are sometimes referred to as the “Press Pulse” protocol.
• Risk of using metformin:
  • Not knowing long term impact of blocking key pathways in cells.
• Exercise has similar cyclical impact as fasting:
  • Damage tissue, repair tissue; also triggers IGF-1 usage.

Key Takeaways:

• Fasting is not a stress on the body, but a shielding and repair mode that we lost over time.
• Prolonged fasting or fasting mimicking diet are the only versions of fasting that trigger the benefits of (IGF-1) cycling.
• Exercise has similar cyclical impact as fasting: damage tissue, repair tissue, trigger IGF-1 for re-growth.
• Prolon FMD: fasting mimicking diet product (https://prolonfmd.com/).

• “Press Pulse” cancer-related fasting protocol:

  • Thomas SEYFRIED Rethinking Cancer Paris 2017 —  (https://www.youtube.com/watch?v=3TZnjC7SR_w&t=309s)

  • Valter LONGO Rethinking Cancer Paris 2017 — (https://www.youtube.com/watch?v=v4ame4E1rtE&t=12s)

  • Adrienne C. Scheck, PhD — The Ketogenic Diet as an Adjuvant to Standard of Care — (https://www.youtube.com/watch?v=vMOhFmY8S-Q)

Worth Listening:

7/10