Why does COVID-19 disproportionately affect the elderly?

By: Amber L. Mueller, Maeve S. McNamara, David A. Sinclair Glenn Center for Biology of Aging Research, Blavatnik Institute, Harvard Medical School Preprint, 30 April 2020 – not peer reviewed. Summary Severity and outcome of COVID-19 largely depends on a

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Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections

By: Alex Zhavoronkov In: Aging Date: 31 March, 2020 Summary COVID-19 disproportionately harms the elderly. Infection rates, severity, and lethality all increase with age. Mostly because of higher levels of comorbidity among elderly. May also be due to decreased immune

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Exercise — Energy Systems and Exercise Zones.

Key Takeaways: Aim for regular moderate intensity exercise: Uses and builds low twitch muscle fibers. These fibers have the highest number of mitochondria – you want more of them. These fibers also help clear lactate. More low twitch fibers =

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The Drive with Peter Attia — David Sinclair

On: Slowing aging – sirtuins, NAD, and the epigenetics of aging Episode: 27 Date: November 2018 Key Subjects: Genetics professor at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging.Sirtuins.Play a key role

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Sirtuins

Summary Introduction. Sirtuins and Gene Silencing. Sirtuins Activity. Sirtuins and Senescence. Introduction Silent information regulator (SIR). Crossroads of nutrient sensing and stress regulation. Responds to energy and nutrients. Controls cellular health. Regulates adaptive response to energy availability. Silences genes. Repairs

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The Drive with Peter Attia — Chris Masterjohn

On: Navigating the many pathways to health and disease Episode: 46 Date: March 2019 Key Subjects: Entrepreneur, independent researcher and doctorate in nutrition.Methylation.See Methylation write-up for more details.Methylation cycle: From methionine to homocysteine.Homocysteine either gets broken down or converted back to

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