The Drive with Peter Attia — David Sinclair

On: Slowing aging – sirtuins, NAD, and the epigenetics of aging

Episode: 27

Date: November 2018

Key Subjects:

  • Genetics professor at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging.
  • Sirtuins.
    • Play a key role in regulating adaptive response to environmental stress (see Sirtuins write-up).
      • Response to heat, caloric restriction, low amino acids, high salt.
      • Switching off genes where needed, repairing DNA.
    • Evolved to deal with adversity, not necessarily to prolong life.
      • Signal to hunker down and survive (and stop breeding).
  • Ageing:
    • Nine hallmarks of ageing (see Ageing write-up).
    • General perspective on ageing: loss of information.
      • The genome gets “scratched”.
      • Changes the way the genome is read (epigenetics, see “The Epigenetics Revolution“)
      • Changes patterns of gene expression.
      • Loss of form and function.
      • Question: how to reset cells, manipulate the epigenome.

Key Takeaways:

  • -/-

Worth Listening:

Helpful introduction to sirtuins and hallmarks of ageing.

  • 7/10

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