The Drive with Peter Attia — David Sinclair

On: Slowing aging – sirtuins, NAD, and the epigenetics of aging Episode: 27 Date: November 2018 Key Subjects: Genetics professor at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging.Sirtuins.Play a key role

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Ageing

Summary Introduction. Ageing and disease. Nine Hallmarks of Ageing. Genomic Instability. Telomere Attrition. Epigenetic Alterations. Cellular Senescence. Deregulated Nutrient Sensing Mitochondrial Dysfunction. Stem Cell Exhaustion. Loss of Proteostasis. Altered Intercellular Communication. Ageing and Cognitive Diseases. Ageing and Dietary Restriction (DR).

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The Drive with Peter Attia — Matt Kaeberlein

On: Rapamycin and dogs — man’s best friends? Episode: 10 Date: August 2018 Key Subjects: Involved in dog ageing research project:Live in similar environment as humans.Die from similar diseases as humans (although cancer is the most common in dogs, versus

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The Drive with Peter Attia — David Sabatini

On: Rapamycin and the discovery of mTOR — the nexus of aging and longevity? Episode: 9 Date: August 2018 Key Subjects: mTOR (mammalian target of rapamycin) (see mTOR write-up) Central regulator of metabolism and physiology. Regulating many cellular processes (cell

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