Summary Introduction. mTOR Activation and Inhibition. Rapamycin. Sources. Introduction Mammalian target of rapamycin (mTOR). Involved in cell metabolism, survival, and growth Central regulator of metabolism and physiology. Regulates many cellular processes. Ccell growth, proliferation, protein synthesis, autophagy. Within the cell,
On: Surviving the Cosmos Episode: 22 Date: December 2015 Key Subjects: Professor in Physics, author of “The Fabric of Reality”, “The Beginning of Inifinty”. Knowledge: A kind of information. It says something that is true and useful about the world.
On: Stephen Fry Episode: 147 Date: February 2019 Key Subjects: Comedian, author, actor, etc. Investigation of empirical evidence and specificity of meditation benefits. Meditation dulls “vices” (anger, greed, insecurity), which are needed as a source of drive and ambition. Defense:
On: Jack Dorsey Episode: 148 Date: February 2019 Key Subjects: CEO of Twitter and Square. General observation: During 2016, journalists on the left barely followed any journalists on the right. Journalists on the right followed many journalists on the left.
On: The Map of Misunderstanding Episode: 150 Date: March 2019 Key Subjects: Nobel Laureate, Professor of Psychology and Public Affairs, co-author of “Thinking Fast and Slow”. On intuition: Intuition really is recognition: of a pattern and the appropriate response to
On: Mental Models Episode: 155 Date: April 2019 Key Subjects: Author of “Mental Models”, founder of Farnam Street blog. How to be better at making decisions – difficulty of bias approach: Retrospectively: cognitive biases are helpful explaining past mistakes. Prospectively:
Summary Introduction. How Insulin May Affect SHBG. How SHBG Affects Free versus Bound Sex Hormones. Impact of Low SHBG. Impact of High SHBG. How to Increase SHBG (When it’s Too Low). How to Reduce SHBG (When it’s Too High). Causes
On: Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease Episode: N/A Date: December 2016 Key Subjects: Attia is focused on things that affect growth factor pathways in the body (mTOR, IGF-1, RAS). What are the links between
On: Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease Episode: N/A Date: December 2016 Key Subjects: See Sulforaphane write-up Potential benefits of sulforaphane, as found in certain leafy vegetables, especially broccoli. Tricky to capture benefits: Eating raw
On: Sauna Use for the Prevention of Cardiovascular & Alzheimer’s Disease Episode: N/A Date: June 2017 Key Subjects: See Sulforaphane write-up Sulforaphane up-regulates variety of beneficial gene pathways, lowering oxidative stress and inflammation. Shown to be effective therapeutic agent in