Summary Introduction. Ageing and disease. Nine Hallmarks of Ageing. Genomic Instability. Telomere Attrition. Epigenetic Alterations. Cellular Senescence. Deregulated Nutrient Sensing Mitochondrial Dysfunction. Stem Cell Exhaustion. Loss of Proteostasis. Altered Intercellular Communication. Ageing and Cognitive Diseases. Ageing and Dietary Restriction (DR).
On: Rapamycin and dogs — man’s best friends? Episode: 10 Date: August 2018 Key Subjects: Involved in dog ageing research project:Live in similar environment as humans.Die from similar diseases as humans (although cancer is the most common in dogs, versus
On: Rapamycin and the discovery of mTOR — the nexus of aging and longevity? Episode: 9 Date: August 2018 Key Subjects: mTOR (mammalian target of rapamycin) (see mTOR write-up) Central regulator of metabolism and physiology. Regulating many cellular processes (cell
Summary Introduction. mTOR Activation and Inhibition. Rapamycin. Sources. Introduction Mammalian target of rapamycin (mTOR). Involved in cell metabolism, survival, and growth Central regulator of metabolism and physiology. Regulates many cellular processes. Ccell growth, proliferation, protein synthesis, autophagy. Within the cell,
Summary Introduction. Causes of Senescent Cells. Process of Senescent Cells Generation. Senescence-Associated Secretory Phenotype (SASP). Effect of Build-up of Senescent Cells. mTOR and Senescence. Role of Telomeres. Potential Fixes. Sources and Links. Introduction Normal cells cease to divide. Maximum of approximately