Summary Introduction. Ageing and disease. Nine Hallmarks of Ageing. Genomic Instability. Telomere Attrition. Epigenetic Alterations. Cellular Senescence. Deregulated Nutrient Sensing Mitochondrial Dysfunction. Stem Cell Exhaustion. Loss of Proteostasis. Altered Intercellular Communication. Ageing and Cognitive Diseases. Ageing and Dietary Restriction (DR).

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FoundMyFitness — Judith Campisi

On: Cellular Senescence, Mitochondrial Dysfunction, Cancer & Aging Episode: N/A Date: April 2017 Key Subjects: See Cellular Senescence write-upSenescent cells form as stress response.Positive: prevents growth of mutant cells/cancer, signals growth to aid tissue repair.Negative: triggers chronic inflammation and immune

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Cellular Senescence

Summary Introduction. Causes of Senescent Cells. Process of Senescent Cells Generation. Senescence-Associated Secretory Phenotype (SASP). Effect of Build-up of Senescent Cells. mTOR and Senescence. Role of Telomeres. Potential Fixes. Sources and Links. Introduction Normal cells cease to divide. Maximum of approximately

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