On: Part IV of V: statins, ezetimibe, PCSK9 inhibitors, niacin, cholesterol and the brain. Episode: 23 Date: October 2018 Key Subjects: Only drugs proven to reduce both cholesterol and CVD events are the ones that target increasing the clearance of
On: Part III of V: HDL, reverse cholesterol transport, CETP inhibitors, and apolipoproteins. Episode: 22 Date: October 2018 Key Subjects: Old school view of cholesterol transport overly simplified: Forward cholesterol transport (FCT). Delivery of cholesterol by VLDL, LDL and chylomicrons
On: Part II of V: Lipid metrics, lipid measurements, and cholesterol regulation. Episode: 21 Date: July 2018 Key Subjects: Lipid basics. Lipoproteins are needed to carry lipids around the bloodstream. The lipids carried primarily include triglycerides, cholesterol, phospholipids. Various types
On: Part I of V: An introduction to lipidology. Episode: 20 Date: October 2018 Key Subjects: Mostly personal introduction to Tom Dayspring. Discussion on benefits of fasting: Most powerful way to deplete glycogen and insulin. Turn nutrient sensing organelles and
On: Stress testing the lipid energy model. Episode: 19 Date: October 2018 Key Subjects: Lean Mass Hyper-Responder (LMHR): Athletic, lean, low carb (and high fat). High levels of LDL-C and LDL-P. High levels of HDL-C. Low levels of TG. Feldman
On: Deep Dive Lp(a). Episode: 7 Date: July 2018 Key Subjects: See Cholesterol write-up. Lp(a) is an LDL particle with an extra apo(a) protein added on, hence the “little a.” Lp(a) molecules differs in size based on length of the
On: A deep dive into heart disease. Episode: 3 Date: July 2018 Key Subjects: See Cholesterol write-up. Importance of measuring LDL particle number vs LDL volume (which is what you get in a standard lipid test). The LDL volume and
This post relies heavily on the blog posts and podcasts of Peter Attia, specifically his nine part series of blog posts entitled “The Straight Dope on Cholesterol” as well as the podcasts episodes of the The Drive with Peter Attia
On: Rapamycin and dogs — man’s best friends? Episode: 10 Date: August 2018 Key Subjects: Involved in dog ageing research project: Live in similar environment as humans. Die from similar diseases as humans (although cancer is the most common in
On: Rapamycin and the discovery of mTOR — the nexus of aging and longevity? Episode: 9 Date: August 2018 Key Subjects: mTOR (mammalian target of rapamycin) (see mTOR write-up) Central regulator of metabolism and physiology. Regulating many cellular processes (cell